No, manual entries/changes to the vendor totals in the 1099 Processing window are not saved to the vendor in AP Manager. Review the work file for corrections prior to making manual changes. If you add them and then have to recreate the work file, you will be asked if you want to delete the current entries prior to creating, and if you say yes, all entries will be deleted. If you say no, you will end up with duplicate entries in the work file and will need to go through and delete the duplications.